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丙戊酸是一种广谱抗癫痫药,为白色结晶性粉末或颗粒,味微涩,有强吸湿性。其作用机制尚不明确,主要用于治疗各型小发作、肌阵挛性癫痫、局限性癫痫、大发作和混合型癫痫发作。丙戊酸口服后在肠内转化为两个丙戊酸钠,延迟吸收。血清丙戊酸水平>500μg/ml与嗜睡、迟钝有关;>1000μg/ml与昏迷伴代谢紊乱(酸中毒、低钙血症和高钠血症)有关。丙戊酸存在肠肝再循环,其活性代谢产物可能具有延迟毒性。
Valproic acid is a broad-spectrum antiepileptic drug that is a white crystalline powder or granule that is slightly astringent and highly hygroscopic. Its mechanism of action is not yet clear, mainly for the treatment of various types of small seizures, myoclonic epilepsy, localized epilepsy, panic attacks and mixed seizures. Valproic acid is converted to two sodium valproate in the intestine orally, with a delay in absorption. Serum valproate levels> 500μg / ml and drowsiness, retardation;> 1000μg / ml and coma with metabolic disorders (acidosis, hypocalcemia and hypernatremia) related. Valproic acid in the presence of enterohepatic recirculation, its active metabolites may have delayed toxicity.