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目的分析加替沙星片联合金钱草清淋合剂治疗男性沙眼衣原体感染性尿道炎的临床疗效。方法 168例男性沙眼衣原体感染性尿道炎患者,随机分为观察组和对照组,每组84例。观察组患者采用加替沙星联合金钱草清淋合剂治疗;对照组患者仅采用加替沙星治疗。比较两组患者临床症状改善时间、治疗效果及不良反应发生情况、沙眼衣原体DNA复检情况。结果观察组患者各临床症状改善时间均明显短于对照组患者,差异具有统计学意义(P<0.05)。治疗2周后,观察组治愈率为90.48%,对照组治愈率为72.62%,观察组治愈率明显高于对照组,差异具有统计学意义(P<0.05);观察组总有效率为97.62%,对照组总有效率为88.10%,观察组总有效率明显高于对照组,差异具有统计学意义(P<0.05)。观察组患者不良反应发生率低于对照组,差异具有统计学意义(P<0.05)。但药物治疗均未对患者的身体造成不良影响,停药后该不良反应消失。经治疗复检后,观察组患者沙眼衣原体DNA复检阴性率为91.67%(77/84),明显高于对照组患者的79.76%(67/84),差异具有统计学意义(P<0.05)。结论加替沙星片联合金钱草清淋合剂治疗男性沙眼衣原体感染性尿道炎临床效果显著,有效缩短患者临床症状改善时间,减少不良反应的发生,避免耐药细菌的出现,在尿路感染治疗中具有极高的临床应用价值。
Objective To analyze the clinical efficacy of gatifloxacin tablets combined with Qiancaoqingling agent in the treatment of male C. trachomatis infectious urethritis. Methods 168 cases of C. trachomatis infectious urethritis were randomly divided into observation group and control group with 84 cases in each group. The patients in the observation group were treated with Gatifloxacin combined with Qianqianqingling Mixture. The patients in the control group were only treated with gatifloxacin. The clinical symptoms of two groups were compared to improve the time, the treatment effect and the incidence of adverse reactions, Chlamydia trachomatis DNA re-examination. Results The improvement time of clinical symptom in observation group was significantly shorter than that in control group, the difference was statistically significant (P <0.05). After 2 weeks of treatment, the cure rate was 90.48% in the observation group and 72.62% in the control group, and the cure rate in the observation group was significantly higher than that in the control group (P <0.05). The total effective rate in the observation group was 97.62% , The total effective rate of the control group was 88.10%, the total effective rate of the observation group was significantly higher than that of the control group, the difference was statistically significant (P <0.05). The incidence of adverse reactions in observation group was lower than that in control group, the difference was statistically significant (P <0.05). However, no adverse effects on the patient’s body caused by drug treatment were observed. After the drug was stopped, the adverse reaction disappeared. After retesting, the negative rate of DNA in the observation group was 91.67% (77/84), which was significantly higher than that in the control group (79.76%, 67/84), the difference was statistically significant (P <0.05) . Conclusions Gatifloxacin tablets combined with Ruxiancaoyuan Mixture in the treatment of C. trachomatis infectious urethritis in men have significant clinical effects, which can effectively shorten the time for improvement of clinical symptoms, reduce the incidence of adverse reactions, avoid the emergence of drug-resistant bacteria in the treatment of urinary tract infection In the high clinical value.