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目的探讨3项炎性指标联合检测在鉴别诊断新生儿感染中的临床效果及应用价值,为早期诊断新生儿感染、及早治疗提供参考依据。方法将医院于2014年2月-2015年7月收治的113例感染新生儿作为研究对象,按照感染类型的不同分为细菌感染组62例和病毒感染组51例,同期选择50名健康新生儿作为对照组;对比3组新生儿血降钙素原(PCT)、白细胞(WBC)及C-反应蛋白(CRP)水平,数据采用SPSS 19.0软件进行统计分析。结果治疗前细菌感染组、病毒感染组新生儿PCT、CRP及WBC水平明显高于对照组;治疗后细菌感染组和病毒感染组新生儿PCT、CRP及WBC水平均明显下降,与治疗前比较差异有统计学意义(P<0.05);3种联合检测方法与PCT单项检测比较,差异有统计学意义(P<0.05)。结论在鉴别诊断新生儿感染,PCT、WBC及CRP水平均可以作为有效指标,而相对于其他联合检测,PCT、CRP及WBC 3项指标联合检测的诊断准确率更高,在鉴别诊断及疗效评价上具有较高的应用价值,值得在临床推广。
Objective To investigate the clinical effect and application value of the joint detection of three inflammatory markers in the differential diagnosis of neonatal infection and provide a reference for early diagnosis of neonatal infection and early treatment. Methods From January 2014 to July 2015, 113 inpatients with neonatal infections admitted to the hospital were divided into two groups: bacterial infection group (62 cases) and virus infection group (51 cases). Fifty healthy newborns As the control group. The levels of neonatal blood procalcitonin (PCT), white blood cells (WBC) and C-reactive protein (CRP) were compared between the three groups. The data were analyzed by SPSS 19.0 software. Results Before treatment, the levels of PCT, CRP and WBC in neonates with bacterial infection and virus infection were significantly higher than those in control group. The levels of PCT, CRP and WBC in neonates with bacterial infection and virus infection were significantly decreased after treatment, compared with those before treatment (P <0.05). There was a significant difference between the three combined detection methods and the PCT single detection method (P <0.05). Conclusions The levels of PCT, WBC and CRP can be used as effective indicators in the differential diagnosis of neonatal infection, and the diagnostic accuracy of the combined detection of PCT, CRP and WBC is higher than that of other combined tests. In the differential diagnosis and evaluation of the curative effect On the higher value, it is worth in the clinical promotion.