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全胰切除术后糖尿病的治疗是一棘手的问题,其最严重的并发症是低血糖休克。本文研究全胰切除术后胰岛素抗体水平的变化与糖尿病治疗的关系。病人和方法:胰岛素抗体的定量测定按略加修改的Nakagawa 方法。结合IRI(免疫反应性胰岛素)=总IRI-游离IRI(μU/ml)。胰岛素抗体的定性分析依据Goldman 方法作平衡结合测定。18例全胰切除后的病人中,11例原先用动物胰岛素,7例用人胰岛素。结果:1.结合IRI 及临床特征:两组患者的年龄分布、性别比例、术后无病(癌)随访期,以及每天胰岛素总注射量相似。全部病例的游离IRI 水平持续低于50μU/ml。7例用人胰岛素治疗的病人在17±20月中的结合
Treatment of diabetes after total pancreatectomy is a thorny issue, and its most serious complication is hypoglycemic shock. This article examines the relationship between changes in insulin levels after total pancreatectomy and diabetes management. PATIENTS AND METHODS: Quantitative determination of insulin antibodies was performed according to the slightly modified Nakagawa method. Binding IRI (immunoreactive insulin) = total IRI - free IRI (μU/ml). Qualitative analysis of insulin antibodies is based on the Goldman method for equilibrium binding assays. Of the 18 patients who underwent total pancreatectomy, 11 were originally treated with animal insulin and 7 were treated with human insulin. Results: 1. Combined with IRI and clinical features: Age distribution, gender ratio, follow-up period after disease free (cancer), and total daily insulin injection were similar in both groups. Free IRI levels remained below 50 μU/ml in all cases. Combination of 7 patients treated with human insulin in 17 ± 20 months