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应用双盲法以单剂量伊维菌素和标准疗程海群生(DEC)各治疗30例班氏丝虫病,曾经海群生3-4疗程治疗后微丝蚴复现的患者、治疗前和服药后1、2、8、14、30、90、180、和360d检测血清中微丝蚴和成虫的抗原和抗体水平。 结果发现:治疗后1-2d,血清HC_(11),ES_(34)抗原水平呈短暂上升,抗ES抗体水平则明显下降。14d,抗ES、抗成虫抗体均明显升高。90d后ES_(34)、HC_(11)抗原下降、ES_(34)降至接近正常水平。但微丝锄复现者有回升趋势。伊维菌素组回升更为明显,表明治疗后血清ES_(34)、HC_(11)监测可能有助于考核药物杀灭成虫的疗效。治疗后初期的抗原上升、抗体下降,似反映有免疫复合物形成可能与副作用的出现有关。
Double-blind method with a single dose of ivermectin and standard treatment of sea Qun (DEC) treatment of 30 cases of Bancroftian filariasis, once the sea group of 3-4 treatment recurrence of microfilaria after treatment, before treatment and medication Antigen and antibody levels of microfilariae and adults in serum were detected at 1, 2, 8, 14, 30, 90, 180, and 360 days after transplantation. The results showed that the level of serum HC_ (11) and ES_ (34) antigen increased temporarily and the level of anti-ES antibody decreased significantly 1-2 days after treatment. 14d, anti-ES, anti-adult antibodies were significantly increased. ES_ (34) and HC_ (11) antigens decreased after 90 days and ES_ (34) decreased to near normal level. However, microfibre recurrence who have a rising trend. The recovery of ivermectin group was more obvious, indicating that serum ES_ (34) and HC_ (11) monitoring after treatment may be helpful in assessing the efficacy of drugs in killing adults. Early treatment of the antigen increased, antibody decreased, it seems that the formation of immune complexes may be related to the emergence of side effects.