Objective:The aim of this study was to study the short-term curative ef ects and adverse reactions of docetaxel (DOC) in concurrent chemoradiotherapy compared to DDP plus 5-Fu (DF) combined with concurrent radiotherapy in patients with advanced nasopharyngeal carcinoma. Methods:Thirty-three patients in the experimental group (DOC group) were given DOC 25 mg/m2 ivgtt, d1, 7 times, concurrent radiotherapy was performed from d1. Thirty-three patients in the control group (DF group) were given cisplatin 25 mg/m2 ivgtt d1-3 and 5-Fu 550 mg/m2 iv, d1-5, 3 weeks a cycle, 2 cycles, and concurrent radiotherapy was performed from d1. Six MV X-ray and 9 MeV electronic line for external irradiation were adopted in concur-rent radiotherapy. Results:The response rates of DOC group and DF group were 90.9%and 93.9%, the rates of neutropenia were 45.45%and 67.74%, and the rates of oral mucositis were 60.61%and 90.32%. Conclusion:The dif erence of short-term curative ef ects between DOC group and DF group was not statistical y significant in patients with advanced nasopha-ryngeal carcinoma. The rates of adverse reactions were lower in DOC group. DOC combined with concurrent radiotherapy could be a new choice for patients with advanced nasopharyngeal carcinoma.