细胞粘附分子系存在于细胞膜上的一类跨膜糖蛋白,主要包括钙粘附素(Cadherins)、整合素(Integrins)、选择素(Selectins)等家族,不同的粘附分子分别介导细胞间及细胞与基质间同质或异质粘附作用。癌的侵袭转移是多阶段的复杂过程,细胞粘附系统的崩溃导致癌细胞脱离母瘤是始动转移的关键。钙粘附索介导钙依较性的细胞间紧密粘附作用,当钙粘附累功能正常时,其他粘附系统功能失活对细 Cell adhesion molecule is a kind of transmembrane glycoprotein which exists in the cell membrane. It mainly includes the families of Cadherins, Integrins, Selectins and so on. Different adhesion molecules mediate cell Between the cells and matrix homogeneous or heterogeneous adhesion. Invasion and metastasis of cancer is a multi-stage complex process. The collapse of cell adhesion system leading to cancer cells from the tumor is the key to the initiation of metastasis. Calcium adhesion cable mediated calcium-dependent intercellular adhesion, when the calcium adhesion function is normal, the other adhesion system function inactivation of fine