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目的观察痰热清、利巴韦林、西咪替丁治疗小儿手足口病的临床效果。方法将86例患儿随机分为两组,对照组42例给予利巴韦林10~15 mg/(kg.d),西咪替丁10~15 mg/(kg.d)静脉滴注,治疗组44例在对照组治疗的基础上加用痰热清注射液0.3~0.5 m l/(kg.d),疗程3~5 d,观察体温、症状体征改善情况。结果治疗组治愈24例,好转19例,总有效率97.7%,对照组治愈16例,好转18例,总有效率81%,两组总有效率比较差异有统计学意义(P<0.05)。结论痰热清、利巴韦林、西咪替丁联合治疗小儿手足口病疗效显著,无不良反应,安全性高。
Objective To observe the clinical effect of Tanreqing, Ribavirin and cimetidine in the treatment of hand-foot-mouth disease in children. Methods Totally 86 children were randomly divided into two groups. The control group received ribavastin 10 ~ 15 mg / (kg · d) and cimetidine 10 ~ 15 mg / (kg.d) In the treatment group, 44 cases were treated with Tanreqing Injection 0.3 ~ 0.5 ml / (kg.d) on the basis of the control group. The course of treatment was 3-5 days. The body temperature and symptom and signs were observed. Results In the treatment group, 24 cases were cured, 19 cases improved, the total effective rate was 97.7%. In the control group, 16 cases were cured, 18 cases improved, and the total effective rate was 81%. There was significant difference between the two groups in total effective rate (P <0.05). Conclusion Tanreqing, ribavirin, cimetidine combined treatment of children with hand, foot and mouth disease significantly effect, no adverse reactions, high safety.