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目的:研究百草枯中毒(PQP)患者血清白介素12(IL-12)的变化。方法:将2014-01-2015-01我院急诊内科住院的PQP患者100例和非PQP患者160例纳入研究,取血清后用酶联免疫吸附试验(ELISA)试剂盒检测IL-12的浓度。结果:PQP患者入院时测得血清中的IL-12浓度中值为1 900(7~2310)pg/ml,160例非PQP患者IL-12浓度中值为<7(<7~41)pg/ml,二者比较差异有统计学意义(P<0.01),治疗后PQP患者IL-12浓度急速下降,但13例PQP死亡患者均发生IL-12下降延迟,且治疗后3~4d的IL-12中值依然在217pg/ml以上,再度上升时患者死亡。结论:IL-12浓度变化可作为PQP患者死亡的预后指标。
Objective: To study the changes of serum interleukin 12 (IL-12) in patients with paraquat poisoning (PQP). Methods: 100 PQPpatients and 160 non-PQPpatients hospitalized in emergency department of our hospital from January 2014 to January 2015 were enrolled in this study. Serum levels of IL-12were detected by enzyme-linked immunosorbent assay (ELISA) kit. Results: The median serum concentration of IL-12 in PQP patients was 1 900 (7-2310) pg / ml at admission, and the median IL-12 concentration in 160 non-PQP patients was <7 (<7-41) pg / ml, the difference between the two groups was statistically significant (P <0.01). After treatment, the IL-12 concentration in PQP patients decreased rapidly. However, the decrease of IL-12 in 13 PQP death patients was delayed. -12 The median remained above 217 pg / ml and the patient died again on ascent. Conclusion: The change of IL-12 concentration can be used as a prognostic indicator of death in patients with PQP.