目的　介绍立体定向微电极导向射频毁损术治疗帕金森病及术后可能出现的并发症。方法　采用 CT定位 ,立体定向微电极细胞电生理记录技术进行术中靶点监测 ,对 10 8例帕金森病人的苍白球和 (或 )丘脑腹外侧核进行射频毁损术治疗。结果　手术效果优良 ,原有症状术后改善率 98.1% ,无永久并发症。结论　立体定向微电极导向射频毁损术是目前治疗帕金森病的一种安全有效方法 Objective To introduce stereotactic microelectrode-guided radiofrequency ablation for the treatment of Parkinson’s disease and possible postoperative complications. Methods The CT targets and stereotactic microelectrode cell electrophysiological recording technique were used to monitor the intraoperative target site. RFP was performed on the globus pallidus and / or hypothalamic ventrolateral nucleus of 108 Parkinson disease patients. Results The operation was excellent, the original symptom postoperative improvement rate was 98.1%, no permanent complications. Conclusion Stereotactic microelectrode-guided radiofrequency ablation is a safe and effective method for the treatment of Parkinson’s disease