目的:探讨低钠血症与新型冠状病毒肺炎（新冠肺炎）患者重症化的关系。方法:回顾性分析2020年1月23日至2月5日汕头市中心医院收治的12例新冠肺炎患者临床资料，包括性别、年龄、主要症状、实验室检查指标及临床转归；分析新冠肺炎患者血Nan +水平变化趋势。n 结果:12例新冠肺炎患者中，男性8例，女性4例，年龄（38.0±16.3）岁，多数病例以咳嗽和（或）发热为主诉入院，2019新型冠状病毒（2019-nCoV）核酸检测均为阳性，经氧疗、抗病毒、抗菌、抗炎和营养支持等综合治疗后均痊愈出院。12例患者入院时均为轻型或普通型，其中1例患者在病程中转为重型，1例出现重型倾向。分析患者血Nan +变化显示，10例未发生重症化或重症倾向患者入院时血Nan +为（138.3±1.3）mmol/L，病程中最低血Nan +为（135.9±3.1）mmol/L；而在病程中转为重型及出现重型倾向的2例患者入院时血Nan +分别为140.0 mmol/L和138.0 mmol/L，在病情加重过程中均出现低钠血症（最低血Nan +分别为129.0 mmol/L和122.0 mmol/L）。进一步分析发现，血Nan +水平降低趋势与白细胞计数（WBC）和C-反应蛋白（CRP）等炎症指标的变化趋势相反，但与淋巴细胞的变化趋势一致，提示低钠血症可能与炎症反应程度密切相关。n 结论:新冠肺炎患者在疾病过程中往往伴随血Nan +降低的倾向；低钠血症与新冠肺炎患者重症化密切相关，在临床诊疗中需要高度重视患者血Nan +变化趋势，但更可靠的结论和具体病理生理机制仍需进一步研究证实。n “,”Objective:To investigate the correlation between hyponatremia and the severity of coronavirus disease 2019 (COVID-19).Methods:Clinical data of 12 patients with COVID-19 admitted to Shantou Central Hospital from January 23 to February 5 in 2020 were retrospectively analyzed, including gender, age, symptoms, lab test and clinical outcomes, to analyze the change trend of blood Nan + level in the patients with COVID-19.n Results:Among the 12 patients with COVID-19, there were 8 males and 4 females with the mean age of (38.0±16.3) years old, most of them were admitted to the hospital with cough and/or fever. All patients had a positive nucleic acid test for 2019 novel coronavirus (2019-nCoV), and were discharged after clinical treatment with oxygen therapy, antiviral, antibacterial, anti-inflammatory, and nutritional support. All patients were of ordinary type when they were admitted to the hospital. Among them, 1 patient turned into a severe case during the course of the disease, and 1 patient showed a tendency to become severe case. It was found that 10 patients without severe conversion had an average blood Nan + of (138.3±1.3) mmol/L at admission, and the lowest blood Nan + during the course of disease was (135.9±3.1) mmol/L. However, 2 patients who became severe and had a tendency to become severe disease (Nan + levels at admission were 140.0 mmol/L and 138.0 mmol/L, respectively) experienced hyponatremia during the course of the disease (the lowest blood Nan + levels were 129.0 mmol/L and 122.0 mmol/L). Further analysis showed that the lower serum Nan + level, the higher level of white blood cell count (WBC) and C-reactive protein (CRP), but serum Nan + level was consistent with the change trend of lymphocytes, suggesting that hyponatremia was closely correlated with severe inflammation reaction.n Conclusions:Serum Nan + showed decreasing tendency during the development of COVID-19, and hyponatremia was closely related to the severity of COVID-19. It was necessary to pay great attention to the change trend of blood Nan + level. However, further research was needed to obtain more reliable conclusions and explorer the pathophysiological mechanisms.n