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目的:研究体质指数(body mass index,BMI)与非吸烟女性肺癌的关系。方法:建立1997—2000年上海市区74942人(其中非吸烟者72829人)、年龄40～70岁的女性队列,每2年随访1次,至2007年12月共收集271例非吸烟女性肺癌病例。用COX回归模型分析BMI与非吸烟女性肺癌发生的相对危险度(relative risk,RR)和95%可信区间(95%confidence interval,95%CI)。结果:调整年龄、教育程度、绝经状态等因素后,基线BMI、20岁BMI与非吸烟女性肺癌危险均无关。基线BMI最高四分组与最低组比较,RR=0.95(95%CI:0.67～1.34);20岁BMI最高四分组与最低组比较,RR=0.77(95%CI:0.52～1.15)。基线BMI和年龄与非吸烟女性肺癌之间关系的分层分析得到相似结果。结论:40岁以上非吸烟女性的BMI可能与其肺癌发生的危险性没有关联。
Objective: To study the relationship between body mass index (BMI) and non-smoking female lung cancer. Methods: A total of 74942 Shanghai residents (including 72829 non-smokers) and female cohorts aged 40-70 years from 1997 to 2000 were recruited. The cohorts were followed up every two years. By December 2007, a total of 271 non-smokers with lung cancer were collected Case. The relative risk (RR) and 95% confidence interval (95% confidence interval) of lung cancer incidence between non-smokers and non-smokers women were analyzed by COX regression model. Results: After adjusting for age, education level and menopausal status, baseline BMI and 20-year-old BMI had no correlation with lung cancer risk in non-smoking women. RR = 0.95 (95% CI: 0.67 to 1.34) for the highest quartile of baseline BMI compared to the lowest, and RR = 0.77 (95% CI: 0.52-1.15) for the highest quartile of 20 years old compared with the lowest. Stratified analysis of the relationship between baseline BMI and age and non-smoking female lung cancer yielded similar results. Conclusion: The BMI of non-smoking women over the age of 40 may not be associated with the risk of lung cancer.