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严重感染(severe sepsis)及其相关的感染性休克(septicshock)和多脏器功能障碍综合征(MODS)是当前 ICU 内主要的死亡原因,也是当代重症医学面临的主要焦点及难点。在美国,每年有75万的严重感染病例发生,超过了充血性心力衰竭或乳腺癌、结肠癌及艾滋病的患病数总和,病死率为20%～63%,与急性心肌梗死的院外病死率相近,且患病率以每年1.5%的比例增长,预计到2010年和2020年,严重感染的患病数将达到93万和110万。美国每年的相关治疗费
Severe infection (sepsis) and its associated septic shock (septicshock) and multiple organ dysfunction syndrome (MODS) are the major causes of death in the current ICU, which is also the main focus and difficulty in contemporary critical care medicine. In the United States, 750,000 serious infections occur every year, exceeding the total number of congestive heart failure or breast cancer, colon cancer and AIDS. The case fatality rate is 20% -63%, which is related to the out-of-hospital mortality rate of acute myocardial infarction Similar, and the prevalence rate of 1.5% per year increase, it is estimated that by 2010 and 2020, the prevalence of serious infections will reach 930,000 and 1.1 million. The United States each year related to treatment costs