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目的:探讨甲氨蝶呤联合环孢素治疗类风湿性关节炎(RA)的临床效果。方法:将2011年10月-2014年10月我院收治的150例RA患者随机分为给予单用甲氨蝶呤治疗的对照组(n=75)和甲氨蝶呤联合环孢素治疗的实验组(n=75),比较两组的疗效。结果:实验组的总有效率明显高于对照组(89.3%vs 70.7%,P<0.05);治疗后,两组患者的关节压痛指数、关节肿胀指数、ESR、CRP均较治疗前明显下降,但实验组患者的关节压痛指数、关节肿胀指数明显低于对照组患者(P<0.05)。结论:甲氨蝶呤联合环孢素治疗RA的疗效明显,且安全性高。
Objective: To investigate the clinical effect of methotrexate combined with cyclosporine in the treatment of rheumatoid arthritis (RA). Methods: One hundred and fifty patients with RA in our hospital from October 2011 to October 2014 were randomly divided into control group (n = 75) treated with methotrexate alone and methotrexate combined with cyclosporine The experimental group (n = 75), the efficacy of the two groups were compared. Results: The total effective rate of the experimental group was significantly higher than that of the control group (89.3% vs 70.7%, P <0.05). After treatment, the joint tenderness index, joint swelling index, ESR and CRP of the two groups were significantly lower than those before treatment However, the joint tenderness index and joint swelling index in the experimental group were significantly lower than those in the control group (P <0.05). Conclusion: Methotrexate combined with cyclosporine in the treatment of RA has obvious curative effect and high safety.