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目的：探讨用吡喹酮与甲苯达唑药盐治疗福建棘隙吸虫病的效果。方法：对１０９例粪检福建棘隙吸虫卵阳性者随机分为４组，分别用吡喹酮（Ａ）５ｍｇ／ｋｇ；（Ｂ）２．５ｍｇ／ｋｇ顿服与甲苯达唑（Ｃ）总剂量８００ｍｇ，８０ｍｇ／ｄ，连服１０ｄ；（Ｄ）总剂量４００ｍｇ，４０ｍｇ／ｄ，连服１０ｄ（药盐）治疗，于治后１ｗｋ和４ｗｋ复查，以虫卵阴转率和减少率为评价疗效。结果：４ｗｋ后上述４组阴转率依次为１００％、９２．３％、８５．２％和７１．４％；虫卵减少率为８４．８％—１００％，Ａ、Ｂ组疗效显著优于Ｄ组。结论：吡喹酮（２．５—５ｍｇ／ｋｇ）疗效高，疗程短，服药简便，为治疗本病的首选药物；甲苯达唑疗效尚可，在伴有肠道线虫感染时可用５００ｍｇ治疗。
Objective: To investigate the effect of praziquantel and mebendazole salts on the treatment of echinococcosis in Fujian Province. Methods: A total of 109 positive cases of Echinococcus granulosus in Fujian Province were randomly divided into 4 groups, treated with praziquantel (A) 5mg / kg and (B) 2.5mg / The total dose of 800mg, 80mg / d, and even served 10d; (D) the total dose of 400mg, 40mg / d, and even served 10d (salt) treatment, 1wk after treatment and 4wk review, Evaluation of efficacy. Results: After 4wk, the negative conversion rates of the above four groups were 100%, 92.3%, 85.2% and 71.4%, respectively. The reduction rates of eggs were 84.8% -100% In group D CONCLUSION: Praziquantel (2.5-5mg / kg) has high curative effect, short course of treatment and simple medication, which is the first choice for the treatment of this disease. Tolbutamide is effective and 500mg can be used in the treatment of intestinal nematode infection.