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雷帕霉素靶蛋白(mammalian target of rapamyoin,mTOR)是进化上高度保守的丝氨酸/苏氨酸蛋白激酶,属于磷脂酰肌醇3-激酶相关激酶(plosphatidylinositol 3-kinase-related kinase,PIKK)蛋白质家族的成员。mTOR作为细胞生长的核心因子,与不同的蛋白质结合时表现出不同的生理功能,参与基因转录、蛋白质翻译起始、核糖体生物合成、细胞周期调控、DNA损伤修复、重组和端粒酶长度的维持等。PIKK家族激酶的功能异常会导致多种代谢性疾病。通过对不同的mTOR相关蛋白信号转导机制的研究,进一步探讨代谢综合征的发病机制,并为相关治疗提供分子靶标。
Mammalian target of rapamyoin (mTOR) is an evolutionarily conserved serine / threonine protein kinase belonging to the family of plosphatidylinositol 3-kinase-related kinase (PIKK) proteins Family members. As the core factor of cell growth, mTOR shows different physiological functions when combined with different proteins and is involved in gene transcription, initiation of protein translation, ribosomal biosynthesis, cell cycle regulation, DNA damage repair, recombination and telomerase length Maintain and so on. Abnormal function of PIKK family kinases leads to a variety of metabolic diseases. Through the study of different mTOR-related protein signal transduction mechanism, to further explore the pathogenesis of metabolic syndrome, and to provide molecular targets for the treatment.