论文部分内容阅读
子宫腺肌病是育龄妇女的一种常见良性疾病,临床上具有侵袭性、种植性、复发性等类似恶性肿瘤的生物学行为,其发病机制尚未阐明。子宫腺肌病的病理改变为具有生理功能的子宫内膜腺体及基质侵入子宫肌层,子宫内膜之所以能在子宫肌层内生长可能与对抗凋亡及降解周围基质及黏附等能力增强有关。Survivin是凋亡抑制家族的新成员,通过抑制凋亡通路发挥抗凋亡作用,与细胞凋亡、增殖有关;基质金属蛋白酶(MMPs)-9是降解细胞外基质及基底膜的主要酶类。两者在子宫腺肌病的发病过程中发挥着重要的作用,本文拟对Survivin和MMP-9在子宫腺肌病发病中的作用作一综述。
Adenomyosis is a common benign disease in women of childbearing age, clinically invasive, implantable, recurrent and other similar biological behavior of malignant tumors, the pathogenesis has not been elucidated. Pathological changes of adenomyosis physiological endometrial glands and matrix invasion of the myometrium, the reason why the endometrium can grow in the myometrium may be related to the ability to resist apoptosis and degradation of the surrounding matrix and adhesion enhanced related. Survivin is a new member of the apoptosis inhibitory family, which exerts its anti-apoptotic effect by inhibiting the apoptosis pathway and is related to apoptosis and proliferation. Matrix metalloproteinases (MMPs) -9 are the major enzymes that degrade extracellular matrix and basement membrane. Both play an important role in the pathogenesis of adenomyosis, this article intends to review the role of Survivin and MMP-9 in the pathogenesis of adenomyosis.