本文报告一组经长期随访的口腔粘膜白斑症,并对其临床特征,病程进展以及癌变因素加以分析。本组257例,其中男125例,女132例。年龄20～89岁,平均54岁。病变范围均在1厘米以上,同时存在2个或2个以上病损者占70％。所有病损均呈疣状型,但许多病人开始为一白斑,其后出现红色斑块成份。随访时间最短6个月,最长8.1年,平均7.2年。手术切除61例,复发21例。癌变率17.5％。作者认为:口腔粘膜白斑确属癌前病变,以随访第2年最高(5％),以后逐渐降低(1.6％～1％)。作者还提出,某些形态学的改变可能是白斑癌变的信号:(1)白斑中杂有红斑成份者比仅有一白斑 This article reports a group of long-term follow-up of oral leukoplakia, and analyzes its clinical features, disease progression, and carcinogenesis. The group of 257 cases, including 125 males and 132 females. Age 20 to 89 years old, average 54 years old. The lesions were more than 1 cm in size, and 7 or more patients had 2 or more lesions at the same time. All lesions were sickle-shaped, but many patients started with a white spot, followed by a red plaque component. The shortest follow-up period was 6 months and the longest was 8.1 years, with an average of 7.2 years. 61 cases underwent surgical resection and 21 cases relapsed. The cancer rate was 17.5%. The authors believe that oral leukoplakia is a precancerous lesion and is highest (5%) in the second year of follow-up, and gradually decreases (1.6% to 1%). The authors also suggest that some morphological changes may be a sign of carcinogenesis in leukoplakia: (1) There is more than one white spot in the white spot.