1,4,5-三磷酸肌醇受体是一种细胞内Ca2+释放通道,它与1,4,5-三磷酸肌醇结合后,引起Ca2+浓度发生改变,从而参与钙信号转导,调节多种细胞代谢活动。近年来,越来越多的研究提示其参与心力衰竭、心肌肥厚、心房颤动等心血管疾病的发生。现就三磷酸肌醇受体的结构、分布、激活Ca2+通道开放以及与心血管疾病发病机制的研究进展等作一综述。 Inositol 1,4,5-trisphosphate receptor is an intracellular Ca2 + release channel, which when combined with inositol 1,4,5-triphosphate, causes a change in Ca2 + concentration and thus participates in calcium signaling, regulating A variety of cell metabolic activities. In recent years, more and more research suggests that it participates in the occurrence of cardiovascular diseases such as heart failure, cardiac hypertrophy and atrial fibrillation. Now on the structure, distribution of inositol 1,4,5-trisphosphate receptor, the opening of Ca2 + channels and the research progress with the pathogenesis of cardiovascular diseases are reviewed.