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Objective: To detect the expression of GAS7 in osteosarcoma and discuss its significance.Methods: Immunohistochemistry SABC method was applied to detect GAS7 expression in specimens of 54 osteosarcoma and 15 osteochondrema cases.Results: The positive expression rate of GAS7 was 74.7%(40/54)in the group of osteosarcema and 0%(0/15)in the group of osteochondroma.There was a significant difference in the comparison of GAS expression in these two groups (P＜0.05).GAS7 was higher expressed in the samples which complicated with relapse or pulmonary metastasis than the control group(P＜0.05).There was no significant association between GAS7 expression and the size of tumor, the gender or the age of the patients(P＞0.05).Conclusion: The hyper-expression of GAS7 may play an important role in the initiation and development of human osteosarcema.