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1简介骨肉瘤是源于间叶组织的恶性肿瘤,以能产生骨样组织的梭形基质细胞为特征。经典型骨肉瘤是原发髓腔内高度恶性肿瘤,肿瘤细胞产生骨样组织。骨肉瘤是最为常见的原发恶性骨肿瘤(每年发病率:2/1000 000～3/1000 000)。可发生于任何年龄,但主要发生于小于20岁较年轻的患者,男女比例约为1.4:1。骨肉瘤可发生于骨骼任何部位,但一般好发于长骨的干骺端。膝关节是最常受累及的部位,约占所有部位的50%,约半数的骨肉瘤发生于股骨,其他
1 Introduction Osteosarcoma is a malignant tumor from mesenchymal tissue characterized by spindle-shaped stromal cells that produce osteoid tissue. The classic osteosarcoma is a highly malignant tumor in the primary medullary cavity. The tumor cells produce bone-like tissue. Osteosarcoma is the most common primary malignant bone tumor (annual incidence: 2/1000 000 ~ 3/1000 000). It can occur at any age, but occurs mainly in younger patients younger than 20 years, with a male to female ratio of about 1.4: 1. Osteosarcoma can occur in any part of the bone, but generally occurs in the metaphysis of long bones. Knee joint is the most commonly involved site, accounting for about 50% of all sites, about half of osteosarcoma occurred in the femur, the other