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目的:观察钩藤碱对大鼠苯丙胺条件性位置偏爱效应的影响及钩藤碱的奖赏效应或厌恶效应。方法:连续给予苯丙胺(2mg/kg,sc,每日1次)4d,引起大鼠产生显著的条件性位置偏爱效应,建立苯丙胺位置偏爱模型。钩藤碱低、中、高剂量(10、20、60mg/kg)+苯丙胺组在训练阶段第2天sc苯丙胺12h后分别按剂量ip给予钩藤碱,氯胺酮+苯丙胺组在训练阶段第3天sc苯丙胺之前15min给予氯胺酮(15mg/kg,ip),均连续3d。钩藤碱+生理盐水组连续给予钩藤碱(60mg/kg,ip,每日1次)4d。结果:钩藤碱各剂量组和阳性药氯胺酮组大鼠在伴药箱的逗留时间均明显缩短,钩藤碱三剂量组随剂量的增加其作用相应增强。钩藤碱+生理盐水组大鼠不形成条件性位置偏爱。结论:预先给予钩藤碱能在一定程度上消除苯丙胺诱导的条件性位置偏爱效应,而钩藤碱本身未显示精神依赖性潜力。
OBJECTIVE: To observe the effect of rhynchophylline on the conditional preference of amphetamine in rats and the reward or aversion effect of rhynchophylline. METHODS: Continuous administration of amphetamine (2 mg/kg, sc, once daily) for 4 days caused rats to produce a significant conditional preference effect, establishing a positional amphetamine preference model. Rhynchophylline low, middle, and high doses (10, 20, 60 mg/kg) plus amphetamine group were administered rapamycin at doses of ip for 12 h after the second day of the training phase, and ketamine was administered ketamine for 3 days during the training phase. Ketamine (15 mg/kg, ip) was administered 15 min before scamphetamine for 3 consecutive days. Rhynchophylline+saline group was given continuous administration of rhynchophylline (60 mg/kg, ip, once daily) for 4 days. RESULTS: The residence time of rat rhynchophylline in each dose group and positive drug ketamine group was significantly shortened in the companion kit. The effect of rhynchophylline three dose group increased with the increase of dose. Rats in rhynchophylline + saline group did not form conditional preference. CONCLUSION: Pre-administration of rhynchophylline can eliminate the effect of amphetamine-induced conditional position preference to a certain extent, while rhynchophylline itself shows no potential for mental dependence.