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[目的]了解血清高敏C-反应蛋白(high-sensitivity C-reactiveprotein,hs-CRP)和肿瘤坏死因子(TNF)-α与老年脑梗塞发生之间的关系。[方法]检测急性期和恢复期93例老年急性脑梗塞组患者和74例正常组对照组的hs-CRP和TNF-α水平,并进行比较分析。[结果](1)脑梗塞组在急性期和恢复期TC差异无统计学意义(P﹥0.05),HDL-C明显低于正常对照组(P﹤0.01);(2)急性期HDL-C明显低于恢复期(P﹤0.01),hs-CRP、TG、TNF-α、LDL-C水平高于恢复期(P﹤0.05);(3)老年脑梗塞患者TNF-α(r=0.548,P﹤0.01)、hs-CRP(r=0.414,P﹤0.01)与LDL-C呈正相关,与HDL-C无相关性;TNF-α与hs-CRP(r=0.326,P﹤0.05)、TG(r=0.552,P﹤0.01)呈正相关。[结论]TNF-α、hs-CRP、LDL-c与老年急性脑梗塞的发生和发展密切相关。
[Objective] To investigate the relationship between serum high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor (TNF) -α and the incidence of cerebral infarction in the elderly. [Methods] The levels of hs-CRP and TNF-α in 93 elderly acute cerebral infarction patients and 74 normal controls were detected in acute and convalescent phases and compared. [Results] (1) There was no significant difference in acute and convalescent TC between cerebral infarction group and HDL-C group (P <0.01); (2) HDL-C (P <0.05); (3) The levels of TNF-α in elderly patients with cerebral infarction (r = 0.548, There was a positive correlation between hs-CRP (r = 0.414, P <0.01) and LDL-C, but no correlation with hs-CRP (r = 0.552, P <0.01). [Conclusion] The levels of TNF-α, hs-CRP and LDL-c are closely related to the occurrence and development of acute cerebral infarction in the elderly.