AIM: To study wound healing activity of the humanplacental extract(HPE) in rats. METIHODS: Fullthickness wounds were inflicted on depilated dorsum ofCharles foster rats with 8 mm Acu-punch biopsy. TheHPE was applied both at topical and im routes (2.5 mL/kg). Effects were compared on the basis of physicalcriteria, biochemical criteria, and histopathological studywith respect to untreated control, vehicle control (1. 5%benzyl alcohol), and framycetin topical treated groups.RESULTS: Significant lowering of wound size(P<0.05), wound index(P<0.05), and number of daysrequired for complete healing (P<0.01); significantgain in tensile strength(P<0.01); appreciable increaseof tissue DNA, total protein, and collagenesis wereobserved in HPE treated group. CONCLUSION:Human placental extract systematically helps collagenesisleading to potent healing of wounds. AIM: To study wound healing activity of the human placental extract (HPE) in rats. METIHODS: Fullthickness wounds were inflicted on depilated dorsum of Charles Foster rats with 8 mm Acu-punch biopsy. TheHPE was applied both at topical and im routes (2.5 mL / Effects were compared on the basis of physical criteria, biochemical criteria, and histopathological study with respect to untreated control, vehicle control (1.5% benzyl alcohol), and framycetin topical treated groups .RESULTS: Significant lowering of wound size (P < (P <0.05), wound index (P <0.05), and number of days forquired for complete healing (P <0.01); significantgain in tensile strength (P <0.01) CONCLUSION: Human placental extract systematically helps collagenesisleading to potent healing of wounds.