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药物以被动扩散通过胃肠膜(屏障),主要是限于脂溶性的。而且吸收速度与吸收部位的药物浓度成正比。但对非电离型与电离型并存的药物来说,上述药物浓度应指非电离型部分的浓度,而不是药物的总浓度。因为解离型的药物一般难溶子
Drugs passively diffuse through the gastrointestinal membrane (barrier), mostly confined to liposolubility. And the speed of absorption is proportional to the drug concentration at the site of absorption. However, for non-ionizing and ionizing coexisting drugs, the above drug concentration should refer to the concentration of the non-ionizing moiety rather than to the total concentration of the drug. Because of dissociation of drugs generally difficult to dissolve child