4-amino-pyrimidine not only has important biological activity[1], but also is the intermediate for some medicines. It can be prepared by cyclotrimerization of nitriles. Meyer[2] found that acetonitrile could be cyclotrimerized to 4-amino-2,6-dimethyl-pyrimidine in the presence of sodium. Excess sodium methoxide or potassium methoxide reacts with acetonitrile to give this product in a sealed equipment at 140 ℃ for 5 h with 70%～80% yield[3,4].