动脉粥样硬化(Atherosclerosis,As)是严重危害人类健康的主要疾病,它是脂质代谢、血凝因素、细胞因子、炎症介质、血流动力学等多种致病因素相互作用的综合结果。近年来的研究发现,白细胞分化抗原40(clusterofdifferentiation40,CD40)广泛存在于动脉粥样硬化斑块的各种细胞中,其相互作用显著影响AS相关细胞的功能,并且与斑块的发生发展密切相关。本文对CD40与冠状动脉粥样硬化斑块内炎症反应的相关问题作一综述。 Atherosclerosis (As) is a major disease that seriously endangers human health. It is a comprehensive result of the interaction of various pathogenic factors such as lipid metabolism, blood clotting factors, cytokines, inflammatory mediators and hemodynamics. In recent years, it has been found that CD40 widely exists in various cells of atherosclerotic plaque and its interaction significantly affects the function of AS-related cells and is closely related to the development of plaque . This article reviews the related problems of CD40 and inflammatory reaction in atherosclerotic plaque.