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目的分析长春市2007~2014年疑似预防接种异常反应(Adverse Events Following Immunization,AEFI)报告质量及其流行性特征。方法对来自长春市2007年1月~2014年12月的AEFI监测系统的个案数据进行描述分析。结果长春市AEFI报告病例数累计9 841例,6和7月份发生构成比高于其他月份,分别为1 002例(10.57%)和960例(10.13%),病例主要集中在0和1岁,分别为4 879例(51.46%)和2 542例(26.81%),异常反应发生率前3位的一类疫苗分别为百日咳-白喉-破伤风联合疫苗(全细胞)(10.28/10万)、麻疹-风疹联合减毒活疫苗(3.12/10万)、麻疹减毒活疫苗(2.19/10万),二类疫苗分别为水痘减毒活疫苗(2.93/10万)、b型流行性感冒嗜血杆菌结合疫苗(2.42/10万)、流感病毒裂解疫苗(1.94/10万)。结论长春市AEFI的监测敏感性逐年升高,婴幼儿发生比重大,且AEFI发生率高于全国平均水平,应加强相关人员的培训,定期开展AEFI工作督导,确保监测工作质量,提高疫苗接种安全性。
Objective To analyze the quality and epidemiological characteristics of reported AEFI in Changchun from 2007 to 2014. Methods The case data of AEFI monitoring system from January 2007 to December 2014 in Changchun City were described and analyzed. Results A total of 9 841 cases of AEFI were reported in Changchun City. The constituent ratios of AEFI reported in Changchun were higher than those in other months (1 002 cases (10.57%) and 960 cases (10.13%) respectively), with the majority of cases being 0 and 1 years old. A total of 4879 cases (51.46%) and 2 542 cases (26.81%), respectively, and the first three cases of unwanted reactions were pertussis-diphtheria-tetanus combined vaccine (whole cell) (10.28 / 100000) Measles-rubella combined attenuated live vaccine (3.12 / 100,000), measles live attenuated vaccine (2.19 / 100,000), the second category vaccines were live attenuated varicella vaccine (2.93 / 100 000), b-type influenza Haemobacterial conjugate vaccine (2.42 / 100,000), influenza virus lysed vaccine (1.94 / 100,000). Conclusion The monitoring sensitivity of AEFI in Changchun City is increasing year by year. The incidence of AEFI is higher than the national average level. The training of related personnel should be strengthened. AEFI supervision should be carried out on a regular basis to ensure the quality of monitoring work and the safety of vaccination Sex.