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目的 探讨纳洛酮试验在急性脑梗死溶栓治疗前的应用价值。方法 33例急性脑梗死患者溶栓治疗前进行纳洛酮试验 ,观察静脉溶栓前后神经功能变化 ,同时观察颅内出血的副作用。结果 纳洛酮试验神经功能缺损评分减少 8分的 2 5例为A组 ,减少不足 8分或评分增加的 8例为B组 ,A组神经功能缺损评分溶栓治疗前(2 4 6 0± 5 2 0 )分 ,治疗后 (5 10± 3 2 0 )分 (P <0 0 1) ,而B组溶栓治疗前 (2 3 90± 4 2 0 )分 ,治疗后 (18 70± 6 2 0 )分 (P >0 0 5 ) ;A组发生颅内出血 1例 ,B组发生 3例 (P <0 0 1)。结论 纳洛酮试验阳性患者溶栓治疗疗效好 ,且颅内出血机率小 ,在溶栓治疗前纳洛酮试验能起到初步筛选病例的作用
Objective To investigate the value of naloxone test before thrombolytic therapy in acute cerebral infarction. Methods 33 patients with acute cerebral infarction were treated with naloxone before thrombolysis. The changes of neurological function before and after intravenous thrombolysis were observed, and the side effects of intracranial hemorrhage were observed. Results 25 cases of naloxone test with neurological deficit score reduced by 8 points were in group A, 8 cases in group A were reduced by less than 8 points or in 8 cases with score increase. Group A had neurological deficit score (2460 ± (P 0.05) before treatment (P 0.05) after treatment, while those in group B before treatment (23 90 ± 42 20) and after treatment (18 70 6 There were 1 case of intracranial hemorrhage in group A and 3 cases in group B (P <0.01). Conclusion Naloxone test positive patients with thrombolytic therapy, and a small chance of intracranial hemorrhage, naloxone test before thrombolytic therapy can play a preliminary screening of cases