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目的:观察枯草杆菌二联活菌颗粒(妈咪爱)和乳果糖治疗儿童功能性便秘的疗效与安全性。方法:将140例儿童功能性便秘患者随机分成两组,乳果糖组71例,妈咪爱组69例。两组均给予常规治疗,乳果糖组给予乳果糖口服溶液,每日早餐时一次性服用;妈咪爱组早晚口服枯草杆菌二联活菌颗粒。结果:乳果糖组总有效率为84.51%,妈咪爱组总有效率为86.96%。两组疗效差异无统计学意义(P>0.05),且不良反应轻微。结论:妈咪爱和乳果糖治疗儿童功能性便秘单用均疗效显著,不良反应轻微,安全性高。但乳果糖改善便秘症状起效更快,尤其是对于病情紧急伴有脱肛和便血的儿童更适合,而妈咪爱在改善食欲和腹胀方面优于前者。
Objective: To observe the curative effect and safety of Bacillus subtilis bivalent live granule (Mommy Love) and lactulose in children with functional constipation. Methods: One hundred and forty children with functional constipation were randomly divided into two groups: 71 in lactulose group and 69 in mommy group. Both groups were given routine treatment, lactulose group given lactulose oral solution, daily taking a one-time breakfast; Mommy love group oral Bacillus subtilis oral live bacteria particles. Results: The total effective rate in lactulose group was 84.51%, and the total effective rate in mommy group was 86.96%. No significant difference between the two groups of efficacy (P> 0.05), and mild adverse reactions. Conclusion: Mommy love and lactulose treatment of functional constipation alone children were significantly effective, minor adverse reactions, high safety. However, lactoferrin improved symptoms of constipation faster onset, especially for children with emergency rectal prolapse and blood in the stool is more suitable, and Mummy love to improve appetite and bloating better than the former.