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法尼醇X受体(farnesoid X receptor,FXR)是一种活性胆汁酸转录因子,调节胆汁酸和脂质内环境稳态急需的基因表达。为证实FXR功能缺失与动脉粥样硬化风险性与严重程度相关,利用FXR-基因敲除小鼠(FXR-/-)与载脂蛋白E基因敲除小鼠(载脂蛋白E-/-)交叉培育出FXR-/-载脂蛋白E-/-双缺失
Farnesoid X receptor (FXR) is an active bile acid transcription factor that regulates genes that are urgently needed for the homeostasis of bile acids and the lipid homeostasis. FXR-knockout mice (FXR - / -) were used in combination with apolipoprotein E knockout mice (apolipoprotein E - / -) to confirm that loss of FXR function is associated with the risk and severity of atherosclerosis Cross-breeding of FXR - / - apolipoprotein E - / - double deletion