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晚期糖基化终产物 (ａｄｖａｎｃｅｄｇｌｙｃａｔｉｏｎｅｎｄｐｒｏｄｕｃｔｓ ,ＡＧＥｓ)的形成是糖尿病血管并发症病理变化的一个特征。ＡＧＥｓ与其受体 (ｒｅｃｅｐｔｏｒｆｏｒＡＧＥｓ,ＲＡＧＥ)结合引起细胞内信号转导的变化 ,激活核转录因子引起靶基因的一系列反应 ,
The formation of advanced glycosylation end products (AGEs) is a hallmark of pathological changes in diabetic vascular complications. AGEs and its receptor (receptorforAGEs, RAGE) combined to cause changes in intracellular signal transduction, activation of nuclear transcription factors cause a series of target gene response,