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目的探讨卵巢交界性肿瘤经保守性手术治疗后进行体外受精-胚胎移植(IVF-ET)治疗的安全性及有效性。方法回顾性分析2009年1月至2014年12月因不孕症就诊、既往卵巢交界性肿瘤行保留生殖功能手术的9例患者(肿瘤组)的临床资料,与同期因不孕症就诊无卵巢交界性肿瘤而行附件切除术病史的9例患者(对照组)按照同质配对方法进行配对,比较两组间的IVF相关指标及肿瘤复发情况。结果 9例肿瘤组和对照组患者生化妊娠分别为4例和5例(P=0.637),临床妊娠分别为3例和5例(P=0.343),活产分别为2例和5例(P=0.147),两组均无流产、早产发生。术后随访18个月,9例肿瘤组患者中1例复发,该患者术后经IVF-ET助孕足月产后半年(术后18个月)时右侧卵巢肿瘤复发。结论卵巢交界性肿瘤实行保留生育功能手术对后续不孕症行体外受精鲜胚移植妊娠结局无显著不良影响。
Objective To investigate the safety and efficacy of in vitro fertilization-embryo transfer (IVF-ET) after conservative surgical treatment of borderline ovarian tumors. Methods The clinical data of 9 patients (tumor group) who had retained reproductive function during the treatment of infertility due to infertility treatment from January 2009 to December 2014 were analyzed retrospectively. No ovary was found in the same period due to infertility Nine patients (control group) with borderline tumor who underwent adjuvant resection were matched according to the method of homogeneous matching, and IVF related indicators and tumor recurrence were compared between the two groups. Results The biochemical pregnancy rates in 9 cases of tumor and control group were 4 cases and 5 cases respectively (P = 0.637), clinical pregnancy were 3 cases and 5 cases (P = 0.343), live birth was 2 cases and 5 cases (P = 0.147), no abortion occurred in both groups, premature birth occurred. After 18 months of follow-up, 1 patient recurred in 9 cases of tumor group. The patient was relapsed right after IVF-ET for 6 months (18 months). Conclusions There is no significant adverse effect on pregnancy outcome after IVF implantation in subsequent infertility with ovarian borderline tumor undergoing fertility preserving surgery.