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阿尔茨海默病(Alzheimer disease,AD)是发病率最高的一种神经退行性疾病,为老年期痴呆主要的类型,随着人均寿命延长,AD发病率越来越高,严重威胁老年人的生活质量。AD病因和病理机制尚不明确,存在tau蛋白异常磷酸化、β-淀粉样蛋白(amyloid-beta protein,Aβ)毒性损伤、基因突变、胆碱能神经系统受损、神经炎症和氧化应激等多种假说。基于各种假说,钩藤在AD模型中已有大量研究。本文结合AD相关病理机制对近年来钩藤在AD模型方面的相关研究进行综述,为进一步开发钩藤药用潜能提供参考资料。
Alzheimer’s disease (AD) is a neurodegenerative disease with the highest incidence. It is the main type of dementia in the elderly. With the prolongation of average life expectancy, the incidence of AD is getting higher and higher, which seriously threatens the elderly Quality of Life. The etiology and pathology of AD are not clear, there are abnormal phosphorylation of tau protein, amyloid-beta protein (Aβ) toxicity, gene mutation, cholinergic nervous system damage, neuroinflammation and oxidative stress Many hypotheses. Based on various hypotheses, Uncaria has been extensively studied in the AD model. In this paper, AD-related pathological mechanisms in recent years Uncaria in the AD model of the related research are reviewed for further development of Uncaria pharmacological potential to provide reference materials.