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目的探讨细胞减灭术及化疗对卵巢上皮性癌的治疗效果及影响因素。方法回顾分析１９８９年１月至１９９３年１月在我院治疗且经细胞减灭术后的卵巢上皮性癌８６例的临床资料。术后均采用ＶＰＣ方案（长春新碱，顺氯氨铂，环磷酰胺）进行化疗。结果总的３年生存率为７４．４２％，５年生存率为５２．５１％。肉眼无残留病灶、残留病灶≤２ｃｍ及残留病灶＞２ｃｍ的５年生存率分别为８１．０８％，５０％及２１．７４％（Ｐ＜０．０１）。化疗疗程数＜８及≥８的５年生存率分别为２２．２％及６６％（Ｐ＜０．０１）。结论经细胞减灭术后，有无残留灶和术后化疗疗程数均与预后有关
Objective To investigate the effect and influencing factors of cytoreductive surgery and chemotherapy on epithelial ovarian cancer. Methods The clinical data of 86 patients with epithelial ovarian cancer after cytoreductive surgery in our hospital from January 1989 to January 1993 were retrospectively analyzed. VPC regimen (vincristine, cisplatin, cyclophosphamide) was used for chemotherapy after operation. Results The overall 3-year survival rate was 74.42% and the 5-year survival rate was 52.51%. The 5-year survival rates of non-residual lesions, residual lesions ≤ 2 cm and residual lesions> 2 cm were 81.08%, 50% and 21.74%, respectively (P <0.01). The 5-year survival rates of chemotherapy courses <8 and ≥8 were 22.2% and 66%, respectively (P <0.01). Conclusion After cytoreductive surgery, there is no residual tumor and the number of postoperative chemotherapy is related to the prognosis