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目的观察小剂量左旋甲状腺素(优甲乐)治疗老年难治性心功能不全并亚临床甲状腺功能减退患者的临床疗效。方法监测老年难治性心功能不全患者的超声心动图、心率、甲状腺功能(游离三碘甲状原氨酸、游离甲状腺素、促甲状腺激素),有亚临床甲状腺功能减退者入组。观察小剂量优甲乐在老年难治性心功能不全合并亚临床甲状腺功能减退者中的临床效果。结果小剂量优甲乐治疗4周后显效20例,有效18例,无效8例,总有效率为83%。结论小剂量优甲乐治疗老年难治性心功能不全并亚临床甲状腺功能减退患者有较好的临床疗效和安全性。
Objective To observe the clinical efficacy of low-dose levothyroxine (Euthyrox) in the treatment of elderly patients with refractory cardiac insufficiency and subclinical hypothyroidism. Methods Echocardiography, heart rate, thyroid function (free triiodothyronine, free thyroxine, thyroid stimulating hormone) in elderly patients with refractory heart failure were monitored. Subclinical hypothyroidism was included in the study. To observe the clinical efficacy of low-dose Euthyrox in elderly patients with refractory cardiac dysfunction and subclinical hypothyroidism. Results After a small dose of Euthyrox treatment for 4 weeks, 20 cases were markedly effective, 18 cases were effective and 8 cases were ineffective. The total effective rate was 83%. Conclusion Efficacy and safety of low-dose Euthyrox in the treatment of elderly patients with refractory cardiac dysfunction and subclinical hypothyroidism have a good clinical efficacy and safety.