铜催化Ullmann C-N偶联反应是一个重要的形成C—N键的有机合成反应。研究表明,合适的配体可以在很大程度上促进铜或铜盐催化的反应活性。新型的配体不断涌现,主要包括N-N、N-O和O-O双齿型配体,极大地推动了铜催化化学的发展。本文综述了添加不同结构配体的铜催化C-N Ullmann偶联反应,并对Ullmann偶联反应的发展前景作了展望。 Copper-catalyzed Ullmann C-N coupling reaction is an important organic synthesis reaction that forms C-N bonds. Studies have shown that suitable ligands can greatly promote copper or copper-catalyzed reactivity. Emerging new ligands, including N-N, N-O and O-O bidentate ligands, have greatly promoted the development of copper catalytic chemistry. In this paper, Cu-catalyzed C-N Ullmann coupling reactions with different ligands were reviewed, and the prospect of Ullmann coupling reaction was prospected.