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本文研究发现,附子汤主要通过降低血浆血栓素B_2(TXB2)的水平,而使6—酮—前列腺素F(1α)(6—K—PGF_(1α))/血栓素B_2(TXB_2)的值明显升高(P<0.05),因而该方具有抑制血小板聚集的作用。拆方研究证明,这一作用主要来自方中芍药。方中人参、附子相配,可明显提高6—K—PGF_(1α)的水平,但同时也大幅度增加了TXB_2的量,两者的比值反而低于对照组。提示方中附子、人参相伍可能具有促血栓形成的倾向。芍药的加入可以改变这一趋势。以党参代替人参后,全方作用没有明显变化,说明配伍后,党参与人参对该项指标显示相似的效应。作为方中主药,单味附子对6—K—PGF_(1α),TXB_2及其比值的影响均不明显,配伍其它药物后,作用才明显提高。
This study found that Fuzi Decoction is mainly used to lower the plasma TXB2 (TXB2) level, which results in the value of 6-keto-prostaglandin F (1α) (6-K-PGF_(1α))/thromboxane B_2 (TXB_2). Significantly increased (P <0.05), so the side has the effect of inhibiting platelet aggregation. Disassembled studies have shown that this effect mainly comes from the prescription drug. The matching of ginseng and aconite in the prescription can significantly increase the level of 6-K-PGF_(1α), but also significantly increase the amount of TXB_2, but the ratio of the two is lower than that of the control group. Propagation of Aconite and Ginseng may have pro-thrombotic tendency. The addition of peony can change this trend. After the replacement of ginseng with Codonopsis pilosula, there was no significant change in the role of all parties, indicating that after the compatibility, the party’s participation in ginseng showed a similar effect on this indicator. As the main drug in the prescription, the effects of mono-taste aconite on 6-K-PGF_(1α), TXB_2 and their ratios were not obvious. After compatibility with other drugs, the effect was significantly improved.