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目的 :探讨C 反应蛋白 (CRP)、凝血因子Ⅰ (FG)在急性冠状动脉综合征 (ACS)发病中的作用及意义。方法 :用速率散射比浊法测定ACS患者各组与非急性冠状动脉综合征 (NACS)组患者血清CRP、FG、肌钙蛋白I(cT nI)、肌酸磷酸激酶(CPK)、肌酸磷酸激酶同工酶 (CPK MB)、乳酸脱氢酶 (LDH)、α 羟丁酸脱氢酶 (α HAD)和谷草转氨酶 (GOT)水平。结果 :ACS患者血清CRP、FG、cTnI、心肌酶谱 (CPK、CPK MB、LDH、α HAD、GOT)峰值水平均显著高于NACS组 (P <0 .0 1 ) ;ACS患者中ST段抬高的心肌梗死 (STAMI)、非ST段抬高的心肌梗死 (NSTAMI)患者组血清CRP、FG、cTnI、心肌酶谱峰值水平均显著高于NACS组 (P <0 .0 1 ) ;不稳定型心绞痛 (UAP)患者组CRP、FG水平显著高于对照组 (P <0 .0 1 ) ,而cTnI、血清心肌酶谱水平与对照组相比差异无统计学意义 (P >0 .0 5 ) ;ACS患者CRP水平与血清cTnI、心肌酶谱峰值水平呈显著正相关 (P <0 .0 1 ) ;FG水平与α HAD峰值水平呈显著正相关 (P <0 .0 1 )。结论 :ACS患者血清CRP与疾病严重程度 (心肌损害)呈正相关。提示CRP可作为ACS发病和预后的预测因子
Objective: To investigate the role and significance of C-reactive protein (CRP) and coagulation factor (FG) in the pathogenesis of acute coronary syndrome (ACS). Methods: The levels of CRP, FG, cTnI, CPK and creatine phosphorylase in serum of patients with ACS and non-acute coronary syndrome (NACS) were measured by speed nephelometry. Kinase isozyme (CPK MB), lactate dehydrogenase (LDH), alpha hydroxybutyrate dehydrogenase (α HAD) and aspartate aminotransferase (GOT) levels. Results: The peak levels of serum CRP, FG, cTnI, myocardial enzymes (CPK, CPK MB, LDH, α HAD and GOT) in patients with ACS were significantly higher than those in NACS patients (P <0.01) Serum levels of CRP, FG, cTnI and myocardial enzymes in patients with high myocardial infarction (STAMI) and non-ST-elevation myocardial infarction (NSTAMI) were significantly higher than those in NACS group (P <0.01) The levels of CRP and FG in patients with angina pectoris (UAP) were significantly higher than those in the control group (P <0.01), while there was no significant difference in cTnI and serum myocardial enzymes between the two groups (P> 0.05) ). There was a significant positive correlation between serum CRP level and serum cTnI and peak myocardial enzyme levels in patients with ACS (P <0.01). There was a significant positive correlation between FG level and peak level of α HAD (P <0.01). Conclusion: Serum CRP in patients with ACS is positively related to the severity of the disease (myocardial damage). Tip CRP can be used as a predictor of ACS onset and prognosis