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目的 :探讨白细胞介素 6 (IL 6 )在应激性溃疡中的作用。方法 :采用Westernblot和免疫组化方法 ,对束缚浸水应激性胃粘膜损伤大鼠脑组织和胃粘膜的蛋白质变化以及IL 6的表达进行分析检测。结果 :束缚浸水应激大鼠 ,下丘脑室旁核及胃粘膜组织均有IL 6的表达 ,并且随着应激时间的延长 ,表达量升高。室旁核中部分IL 6阳性细胞同时表达c fos蛋白。结论 :提示IL 6可能作用于中枢引起神经内分泌的变化而参与应激性溃疡的形成
Objective: To investigate the role of interleukin 6 (IL 6) in stress ulcer. Methods: Western Blot and immunohistochemistry were used to detect the protein changes of brain tissue and gastric mucosa and the expression of IL-6 in stress-induced gastric mucosal injury in rats. Results: The binding capacity of water immersion in rats, hypothalamic paraventricular nucleus and gastric mucosal tissue IL 6 expression, and with the prolonged stress, the expression increased. Paraventricular nucleus in part of IL 6-positive cells express c fos protein. Conclusion: It is suggested that IL 6 may play a central role in neuroendocrine changes and participate in the formation of stress ulcer