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观察了链脲佐菌素糖尿病大鼠成模两个月后,投用神经生长因子(NGF)对糖尿病神经病变的影响。结果显示,外源性注射NGF1个月后,摇尾试验(一种鼠对热毒刺激的反应)热痛阈值明显恢复,坐骨神经的感觉神经传导速度有所改善。初步显示了NGF对糖尿病感觉神经病变的治疗作用。
The effect of using nerve growth factor (NGF) on diabetic neuropathy was observed after two months of STZ diabetic model. The results showed that after a single month of exogenous injection of NGF, the heat stroke threshold (a rat’s response to thermo-toxic stimulus) was significantly restored and the sensory nerve conduction velocity of the sciatic nerve improved. Preliminary demonstration of the therapeutic effect of NGF on diabetic sensory neuropathy.