我院1989年2月至1996年2月,共对146例年龄在15～35岁的育龄女性进行了心脏机械瓣膜置换术,术后予华法林常规抗凝治疗并进行了术后随访,随访时间为1～8年。作者认为,调整术后抗凝方案,减少华法林用量,使凝血酶原时间为正常对照的1.5～2.0倍,不仅能有效地预防血栓栓塞,而且能明显地减少出血并发症,提高育龄女性妊娠分娩的安全性,减轻抗凝治疗对子代的影响。 Our hospital from February 1989 to February 1996, a total of 146 cases of women aged 15 to 35 years of age women underwent heart valve replacement mechanical heart surgery, warfarin after conventional anticoagulant therapy and were followed up, Follow-up time of 1 to 8 years. The authors believe that adjusting the postoperative anticoagulation regimen and reducing the amount of warfarin so that the prothrombin time 1.5 to 2.0 times the normal control, not only can effectively prevent thromboembolism, but also significantly reduce bleeding complications and improve women of childbearing age The safety of pregnancy and childbirth, reducing the impact of anticoagulant therapy on offspring.