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目的研究联合吸入布地奈德混悬液、特布他林雾化液、异丙托溴铵溶液治疗毛细支气管炎的疗效及安全性。方法采用随机抽样法将98例毛细支气管炎患儿分为治疗组和对照组两组,每组49例。对照组予常规治疗,治疗组在常规治疗基础上加用吸入布地奈德混悬液、特布他林雾化液、异丙托溴铵溶液进行治疗。观察比较两组疗效及安全性。结果治疗组在喘息、嗽咳、肺部哮鸣音及湿啰音消失天数、住院天数等方面均明显短于对照组,差异均有统计学意义(P<0.05)。治疗组治愈37例,好转10例,无效2例,总有效率为95.9%;对照组治愈24例,好转14例,无效11例,总有效率为77.6%。两组总有效率比较差异有统计学意义(χ2=7.81,P<0.01),治愈率比较差异有统计学意义(χ2=7.34,P<0.01)。结论联合吸入布地奈德混悬液、特布他林雾化液、异丙托溴铵溶液治疗毛细支气管炎疗效明显,并且不良反应少,安全性好。
Objective To study the efficacy and safety of combined inhalation of budesonide suspension, terbutaline nebulization solution and ipratropium bromide solution in the treatment of bronchiolitis. Methods A total of 98 children with bronchiolitis were randomly divided into treatment group and control group, with 49 cases in each group. The control group was given routine treatment. The treatment group was treated with inhaled budesonide suspension, terbutaline atomization solution and ipratropium bromide solution on the basis of routine treatment. Observed and compared the efficacy and safety of the two groups. Results The treatment group was significantly shorter than the control group in wheezing, cough, lung wheeze and wet rales disappearance days, days of hospitalization and so on, the difference was statistically significant (P <0.05). In the treatment group, 37 cases were cured, 10 cases improved, 2 cases ineffective and the total effective rate was 95.9%. In the control group, 24 cases were cured, 14 cases improved, and 11 cases were ineffective. The total effective rate was 77.6%. There was significant difference between the two groups in the total effective rate (χ2 = 7.81, P <0.01). The cure rate was significantly different (χ2 = 7.34, P <0.01). Conclusions The combined inhalation of budesonide suspension, terbutaline nebulization solution and ipratropium bromide solution for the treatment of bronchiolitis have obvious curative effect with less adverse reactions and good safety.