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研究目的急性下呼吸道感染（ALRI）时血管内皮细胞损伤机制及其临床意义。研究方法ALRI患儿36例，正常健康儿童30例为对照组。测定一氧化氮（NO）水平及循环内皮细胞（CEC）数量。研究结果NO的稳定代谢产物—循环亚硝酸／硝酸根离子（NO2-／NO3－）水平，对照组为24．5±14.1μmol／L，ALRI组为44．6±22．6μmol／L，差异显著（P＜0．05）。CEC数量对照组5．5±2．1n／0．09μl，ALRI组为10．7±5．1n／0，09μl，差异亦显著（P＜0．05）。经Spearman相关检验NO2－／NO3-水平与CEC数量显著相关（P＜0．05）。结论ALRI时NO对血管内皮细胞（VEC）损伤起着重要作用，其临床意义值得深入探讨。
Objective To investigate the mechanism of vascular endothelial cell injury in acute lower respiratory tract infection (ALRI) and its clinical significance. Methods 36 children with ALRI and 30 healthy children were selected as the control group. The level of nitric oxide (NO) and the number of circulating endothelial cells (CEC) were measured. RESULTS: The steady-state metabolites of nitric oxide / nitrite (NO2- / NO3-) were 24.5 ± 14.1 μmol / L in the control group and 44.6 ± 22.6 μmol / L in the ALRI group Significant (P <0.05). The number of CEC was 5.5 ± 2.1n / 0.09μl in control group and 10.7 ± 5.1n / 0,09μl in ALRI group (P <0.05). The Spearman correlation test showed that NO2- / NO3- levels were significantly correlated with the number of CECs (P <0.05). Conclusion NO at ALRI plays an important role in the injury of vascular endothelial cells (VECs), and its clinical significance deserves further exploration.