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[目的]观察连芙胃和口服液联合奥美拉唑和阿莫西林治疗幽门螺杆菌(H.pylori,Hp)感染的临床疗效、安全性和成本效果。[方法]86例Hp感染患者随机分为2组,试验组42例,予连芙胃和口服液20ml加奥美拉唑20mg加阿莫西林l.0g,2次/d;对照组44例,予奥美拉唑20mg加阿莫西林1.0g加克拉霉素500mg,2次/d口服;疗程均为1周。观察主要疗效指标Hp根除率;次要疗效指标临床症状疗效总有效率、不良反应发生率和成本-效果比。[结果]试验组和对照组的Hp根除率分别为71.05%和75.00%(P>0.05),临床症状疗效总有效率分别为94.74%和75.61%(P<0.05),不良反应发生率分别为5.26%和34.09%(P<0.01),成本-效果比之差为119.18元。[结论]连芙胃和口服液联合奥美拉唑和阿莫西林是一种有效、安全和经济的根除Hp治疗方案。
[Objective] To observe the clinical efficacy, safety and cost-effectiveness of Lian Fu Wei and oral liquid combined with omeprazole and amoxicillin in the treatment of H.pylori infection. [Method] Eighty-six patients with Hp infection were randomly divided into two groups. The experimental group consisted of 42 cases, with Fufuguwei Oral Liquid 20ml plus omeprazole 20mg plus amoxicillin 1.0g twice daily, and control group 44 cases , Omeprazole 20mg plus amoxicillin 1.0g plus clarithromycin 500mg, 2 times / d orally; course of treatment were 1 week. The main efficacy indicators Hp eradication rate; secondary efficacy indicators clinical efficacy of the total effective rate, the incidence of adverse reactions and cost-effectiveness ratio. [Results] The eradication rates of Hp in experimental group and control group were 71.05% and 75.00% respectively (P> 0.05), and the total effective rates of clinical symptoms were 94.74% and 75.61% (P <0.05) respectively. The incidence of adverse reactions were 5.26% and 34.09%, respectively (P <0.01), and the cost-effectiveness ratio was 119.18 yuan. [Conclusion] Lian Fu Wei and oral liquid combined omeprazole and amoxicillin is an effective, safe and economical eradication Hp treatment.