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Objective: To explore the clinical medication law of Professor Liu Taofeng in the treatment of eczema by using data mining technology. Methods: the cases of eczema treated by Professor Liu Taofeng in the outpatient department of the First Affiliated Hospital of Anhui University of traditional Chinese medicine from June 2018 to October 2019 were collected and sorted out. The database was established with the help of Microsoft Excel 2016, SPSS statistical 24.0 and SPSS modeler 18.0 computer software, and the frequency analysis, high-frequency drug association rule analysis and cluster analysis were carried out. Results: among the 255 prescriptions included in the study, 41 traditional Chinese medicines were involved, and the top 10 drugs were fresh white skin, cortex Scutellariae, Cortex Moutan, Tribulus terrestris, Sophora flavescens, Salvia miltiorrhiza, Atractylodes macrocephala, Poria cocos, liquorice, and Cynanchum paniculatum; 10 pairs of 2 drugs were associated by association analysis, such as Tribulus terrestris → fresh white skin, Sophora flavescens → cortex Scutellariae; and Poria cocos, Atractylodes macrocephala, lentils were obtained by cluster analysis. Conclusion: Professor Liu Taofeng paid more attention to the heart and liver in the treatment of eczema, taking clearing away heat, cooling blood and removing dampness as the main treatment, and paid more attention to invigorating the spleen and stomach or removing blood stasis.