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目的对采用盐酸纳洛酮注射液治疗乙醇中毒68例进行临床观察。方法对照组患者给予常规治疗及静脉补液,治疗组在对照组的基础上给予盐酸纳洛酮注射液,直至清醒。结果治疗组平均清醒时间为100±40分钟,对照组平均清醒时间为为190±70分钟,两组比较治疗组较对照组明显缩短(P<0.05)。结论盐酸纳洛酮抢救乙醇中毒具有催醒快、疗程短、疗效确切、副作用小等优点,对伴有昏迷及低血压者效果尤佳,是救治乙醇中毒较为理想的药物,值得临床推广使用。
Objective To observe the clinical effect of naloxone hydrochloride injection on alcohol poisoning in 68 patients. Methods Patients in the control group were given conventional therapy and intravenous fluid replacement. The treatment group was given naloxone hydrochloride injection on the basis of the control group until awake. Results The mean awake time was 100 ± 40 minutes in the treatment group and 190 ± 70 minutes in the control group. The two groups were significantly shorter than the control group (P <0.05). Conclusion Naloxone hydrochloride has the advantages of prompt reminiscence, short course of treatment, definite curative effect and small side effects. It is especially effective for coma and hypotension, which is an ideal drug for treating alcohol poisoning. It is worth to be used clinically.