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目的探讨大蒜素亚慢性染毒对雄性大鼠某些生化指标的影响。方法以3.3、10和30 mg/kg的剂量经口灌胃大蒜素给予雄性大鼠,染毒90 d后,测定大鼠血常规、血生化指标;并以Western Blot法测定雄性大鼠脾细胞内Toll样受体-4(TLR-4)、核因子κB(NF-κB)、信号调节蛋白α(SIRPα)表达的改变。结果大蒜素亚慢性染毒对雄性大鼠血常规和血生化指标无明显影响。3.3、10和30 mg/kg剂量组的TLR-4和NF-κB的表达和30 mg/kg剂量组SIRPα表达与对照组比较,差异有统计学意义(P<0.05或P<0.01)。结论大蒜素亚慢性染毒能明显上调雄性大鼠脾细胞内TLR-4、NF-κB、SIRPα的表达水平。
Objective To investigate the effects of allicin subchronic exposure on some biochemical indexes in male rats. Methods The rats were orally administered with allicin at dosages of 3.3, 10 and 30 mg / kg, and the blood routine and blood biochemical indexes of rats were determined 90 days after exposure. The splenocytes of male rats were determined by Western Blot Toll-like receptor 4 (TLR-4), nuclear factor kappa B (NF-κB) and signal regulatory protein α (SIRPα). Results The sub-chronic allicin exposure had no significant effect on the blood and blood biochemical parameters in male rats. Compared with the control group, the expression of TLR-4 and NF-κB in the 3, 10 and 30 mg / kg dose groups and the control group were significantly different (P <0.05 or P <0.01). Conclusion Allotin can significantly up-regulate the expression of TLR-4, NF-κB and SIRPα in spleen cells of male rats.