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目的探讨双歧三联活菌治疗亚临床肝性脑病(SHE)的疗效。方法经智力测验(数字连接试验)诊断SHE64例,随机分为对照组和治疗组各32例。对照组服复合维生素B,治疗组服双歧三联活菌片,25周为1疗程。治疗前后测定血氨、丙氨酸转氨酶、数字连接试验,统计治疗期间肝性脑病(HE)的发病率。结果治疗组治疗后血氨、ALT、NCT较治疗前显著改善,且明显优于对照组(P<0.05或P<0.01),治疗组HE发病率显著低于对照组(P<0.01)。结论双歧三联活菌维持治疗SHE能够降低血氨,改善智力测验结果,降低HE的发病率。
Objective To investigate the efficacy of Bifidobacterium triplex in the treatment of subclinical hepatic encephalopathy (SHE). Methods 64 cases of SHE were diagnosed by intelligence test (digital connection test) and randomly divided into control group and treatment group of 32 cases. The control group took vitamin B complex, the treatment group served Bifidobacterium triple viable tablets, 25 weeks for a course of treatment. Blood ammonia and alanine aminotransferases were measured before and after treatment, and the number of connections was tested. The incidence of hepatic encephalopathy (HE) was calculated during treatment. Results The levels of serum ammonia, ALT and NCT in the treatment group were significantly improved after treatment, which were significantly better than those in the control group (P <0.05 or P <0.01). The incidence of HE in the treatment group was significantly lower than that of the control group (P <0.01). Conclusion Bifidobacterium trifoliatum maintains SHE can reduce blood ammonia, improve intelligence test results and reduce the incidence of HE.