【摘 要】
：
Complex behaviors in genetic neurological disorders have traditionally been viewed through the prism of genetic influences on brain development and function.In a recent study published in Cell,Costa-Mattioli and colleagues make a compelling argument that
【机 构】
：
APC Microbiome Ireland,University College Cork,Cork,Ireland;APC Microbiome Ireland,University Colleg
论文部分内容阅读
Complex behaviors in genetic neurological disorders have traditionally been viewed through the prism of genetic influences on brain development and function.In a recent study published in Cell,Costa-Mattioli and colleagues make a compelling argument that the gut microbiome and the host genes can interdependently regulate different behaviors in a genetic mouse model of autism.
其他文献
Dear Editor,rnNicotinic acetylcholine receptors (nAChRs) are a class of pentameric ligand-gated ion channels (pLGICs) widely expressed in nervous system.nAChRs function as neurotransmitter receptors that respond to endogenous acetylcholine and choline,mod
In a recent study published in Science,Hernandez-Lopez et al.engineered a low-to-high two-step regulatory circuit that allows T cells to discriminate target antigens with an ultrasensitive threshold.In this circuit,low-affinity synNotch receptor controls
Dear Editor,rnThe SARS-CoV-2 virus has infected over one hundred million people (COVID-19 patients) and caused more than two million deaths to date.The number of infected people continues to grow quickly,emphasizing the need for rapid use of effective vac
How do we free ourselves from outdated routines when conditions change?Park et al.show that a novel experience can weaken old connections within the brain\'s memory system,thereby freeing up resources to learn something new.rnRoutines are common solutio
Dear Editor,rnClostridium novyi(C.novyi)is a spore-forming anaerobic bacterium and opportunistic pathogen causing severe infectious diseases in humans and animals including gas gangrene,myositis,necrotic hepatitis,and sepsis.1,2 The alpha-toxin(Tcnα)is th
The identification and development of biased modulators of proximal G protein-coupled receptor (GPCR) signaling to prevent pathological disease progression has been at the forefront of recent drug discovery efforts.Recently,Fu et al.identified cartilage o
Dear Editor,rnSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)has become a severe threat to global health.1 The spike (S) protein on the surface of SARS-CoV-2 exploits angiotensin-converting enzyme 2 (ACE2) as cellular receptor and mediates th
Dear Editor,rnThe highly conserved neuropeptides arginine vasopressin(AVP)and oxytocin(OT)signal through a family of Class A G protein-coupled receptors(GPCRs),the AVP receptors V1aR,V1bR and V2R and the OT receptor OXTR.1,2 V2R is predominantly found in
Retrotransposons are highly abundant mobile genetic elements in mammalian genomes and can interfere with many genomic processes,particularly the transcription of genes.A study by Xiong et al.reveals that segments of nascent RNAs containing retrotransposon
The endocrine pancreas is composed of islets of Langerhans that are scattered throughout the gland and contain multiple hormone-producing cell types(a,β,δ,PP and ε cells);endocrine progenitors(EPs)can differentiate into these distinct lineages,but the reg